A high index of suspicion is required for patients who show signs and symptoms of drug abuse or dependency. A complete evaluation of the patient is necessary, including physical examination and laboratory investigations. The clinical diagnosis of the patient is facilitated by the presence of specific signs – for example, nasal ulceration in cocaine abuse. Nevertheless, it is common for patients to have non-specific complaints related to drug withdrawal. A wide range of signs and symptoms has been attributed to drug abuse, including constricted or dilated pupils, coarse voice, abnormal heart rate, enlarged liver, and collapsed veins.